HIV infection with concomitant cerebral toxoplasmosis and disseminated histoplasmosis in a 45-year-old man.
Identifieur interne : 000C45 ( Main/Exploration ); précédent : 000C44; suivant : 000C46HIV infection with concomitant cerebral toxoplasmosis and disseminated histoplasmosis in a 45-year-old man.
Auteurs : Masayuki Murata [Japon] ; Norihiro Furusyo ; Shigeru Otaguro ; Shigeki Nabeshima ; Iwao Ariyama ; Jun HayashiSource :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [ 1341-321X ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Histoplasma (génétique), Histoplasma (isolement et purification), Histoplasmose (), Histoplasmose (sang), Histoplasmose (virologie), Humains, Infections opportunistes liées au SIDA (microbiologie), Infections opportunistes liées au SIDA (parasitologie), Infections à VIH (), Issue fatale, Mâle, Syndrome de détresse respiratoire de l'adulte, Toxoplasmose cérébrale (), Toxoplasmose cérébrale (anatomopathologie), Toxoplasmose cérébrale (virologie), Voyage.
- MESH :
- anatomopathologie : Toxoplasmose cérébrale.
- génétique : Histoplasma.
- isolement et purification : Histoplasma.
- microbiologie : Infections opportunistes liées au SIDA.
- parasitologie : Infections opportunistes liées au SIDA.
- sang : Histoplasmose.
- virologie : Histoplasmose, Toxoplasmose cérébrale.
- Adulte d'âge moyen, Histoplasmose, Humains, Infections à VIH, Issue fatale, Mâle, Syndrome de détresse respiratoire de l'adulte, Toxoplasmose cérébrale, Voyage.
English descriptors
- KwdEn :
- AIDS-Related Opportunistic Infections (microbiology), AIDS-Related Opportunistic Infections (parasitology), Fatal Outcome, HIV Infections (complications), Histoplasma (genetics), Histoplasma (isolation & purification), Histoplasmosis (blood), Histoplasmosis (complications), Histoplasmosis (virology), Humans, Male, Middle Aged, Respiratory Distress Syndrome, Adult, Toxoplasmosis, Cerebral (complications), Toxoplasmosis, Cerebral (pathology), Toxoplasmosis, Cerebral (virology), Travel.
- MESH :
- blood : Histoplasmosis.
- complications : HIV Infections, Histoplasmosis, Toxoplasmosis, Cerebral.
- genetics : Histoplasma.
- isolation & purification : Histoplasma.
- microbiology : AIDS-Related Opportunistic Infections.
- parasitology : AIDS-Related Opportunistic Infections.
- pathology : Toxoplasmosis, Cerebral.
- virology : Histoplasmosis, Toxoplasmosis, Cerebral.
- Fatal Outcome, Humans, Male, Middle Aged, Respiratory Distress Syndrome, Adult, Travel.
Abstract
Although disseminated histoplasmosis is a common opportunistic infection in HIV patients in endemic areas, it is not widely known in Japan. We report a rare case of a man from Ghana infected with HIV who was hospitalized in Japan and who suffered from coinfection with cerebral toxoplasmosis and disseminated histoplasmosis. The diagnosis of cerebral toxoplasmosis was confirmed by a brain biopsy, and the therapy for the disease resulted in almost complete resolution of the brain lesion. However, fever of unknown origin continued for 2 weeks, and disseminated histoplasmosis was diagnosed by examination of a blood smear and by the detection of the histoplasma genome in the peripheral blood by means of polymerase chain reaction. The isolate was confirmed to be Histoplasma capsulatum var. duboisii. Therapy with amphotericin B was initiated, and no histoplasma genome in the peripheral blood was detected 3 days later. Unfortunately, the patient died after 10 days from acute respiratory syndrome. This case highlights that histoplasmosis should be included in the differential diagnosis of opportunistic infections in AIDS patients when patients have a history of travel to or arrival from endemic areas.
DOI: 10.1007/s10156-006-0486-3
PubMed: 17334730
Affiliations:
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Le document en format XML
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first="Shigeru" last="Otaguro">Shigeru Otaguro</name></author><author><name sortKey="Nabeshima, Shigeki" sort="Nabeshima, Shigeki" uniqKey="Nabeshima S" first="Shigeki" last="Nabeshima">Shigeki Nabeshima</name></author><author><name sortKey="Ariyama, Iwao" sort="Ariyama, Iwao" uniqKey="Ariyama I" first="Iwao" last="Ariyama">Iwao Ariyama</name></author><author><name sortKey="Hayashi, Jun" sort="Hayashi, Jun" uniqKey="Hayashi J" first="Jun" last="Hayashi">Jun Hayashi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17334730</idno><idno type="pmid">17334730</idno><idno type="doi">10.1007/s10156-006-0486-3</idno><idno type="wicri:Area/PubMed/Corpus">000623</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000623</idno><idno type="wicri:Area/PubMed/Curation">000623</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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We report a rare case of a man from Ghana infected with HIV who was hospitalized in Japan and who suffered from coinfection with cerebral toxoplasmosis and disseminated histoplasmosis. The diagnosis of cerebral toxoplasmosis was confirmed by a brain biopsy, and the therapy for the disease resulted in almost complete resolution of the brain lesion. However, fever of unknown origin continued for 2 weeks, and disseminated histoplasmosis was diagnosed by examination of a blood smear and by the detection of the histoplasma genome in the peripheral blood by means of polymerase chain reaction. The isolate was confirmed to be Histoplasma capsulatum var. duboisii. Therapy with amphotericin B was initiated, and no histoplasma genome in the peripheral blood was detected 3 days later. Unfortunately, the patient died after 10 days from acute respiratory syndrome. This case highlights that histoplasmosis should be included in the differential diagnosis of opportunistic infections in AIDS patients when patients have a history of travel to or arrival from endemic areas.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Ariyama, Iwao" sort="Ariyama, Iwao" uniqKey="Ariyama I" first="Iwao" last="Ariyama">Iwao Ariyama</name><name sortKey="Furusyo, Norihiro" sort="Furusyo, Norihiro" uniqKey="Furusyo N" first="Norihiro" last="Furusyo">Norihiro Furusyo</name><name sortKey="Hayashi, Jun" sort="Hayashi, Jun" uniqKey="Hayashi J" first="Jun" last="Hayashi">Jun Hayashi</name><name sortKey="Nabeshima, Shigeki" sort="Nabeshima, Shigeki" uniqKey="Nabeshima S" first="Shigeki" last="Nabeshima">Shigeki Nabeshima</name><name sortKey="Otaguro, Shigeru" sort="Otaguro, Shigeru" uniqKey="Otaguro S" first="Shigeru" last="Otaguro">Shigeru Otaguro</name></noCountry><country name="Japon"><noRegion><name sortKey="Murata, Masayuki" sort="Murata, Masayuki" uniqKey="Murata M" first="Masayuki" last="Murata">Masayuki Murata</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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